The actress will be joining a string of A-Listers raising awareness for homelessness across the world while taking part in a sleep-out, in the iconic Trafalgar Square.
Dame Helen, 74, will lead the events by telling a bedtime story to people taking part in Trafalgar Square, with Men in Black star, Will Smith telling those in Manhattan's Times Square a bedtime story.
It is believed that there are currently 100 million people worldwide are currently homeless, with the number of those dying on the streets in the UK around two per week.
The number of those sleeping rough in England alone has risen by more than 150% since 2010, with more than 125,000 children without a place to call home.
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Stars are set to join forces on December 7th in what is believed to be the largest fundraising event in a generation, hoping to raise £40 million in one evening.
Cities across the globe are due to take part in official events, held in London, Manhattan, Los Angeles, Manchester, Belfast, Newcastle, Madrid and many more.
People are encouraged to join an official event or "Host Your Own" in their back garden, office car park, high school or university.
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Dame Helen said: "Homelessness on our streets is a real problem in the UK and for many nations throughout the world.
"This coupled with an unprecedented number of refugees being displaced internationally makes this a really important time to focus attention on the issue of global homelessness."
The actress famed for her iconic roles went on to add: "The World's Big Sleep Out campaign will play an important role in shining the political spotlight on the issues of homelessness and displacement whilst raising considerable funds to make a big difference.
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"I am pleased to have this opportunity to make a contribution by performing a bedtime story for participants in London, which will also be screened at sleep out events happening throughout the world.
"I'd like to encourage anyone who cares about this issue to get involved by sleeping out, in solidarity with those who have no choice, on 7th December."
Josh Littlejohn MBE has been spearheading the campaign after launching Social Bite, one of the main driving forces behind tackling homelessness in Scotland.
A quarter of the staff at Social Bite are homeless and they were recently visited by Hollywood legends, George Clooney and Leonardo DiCaprio.
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